Laser- or light-based dermatological procedures such as removal of pigmented lesions, facial rejuvenation, and skin tightening are increasing in frequency.
Occlusive therapy has been used in psoriasis, but the effects of occlusion on psoriasis are not completely understood (see e.g., Hwang et al., Internat. These side effects limit the utility of existing therapies due to the risks presented, and exclude patient populations who suffer from preexisting immunocomprised conditions or those whose medication regimen preclude use of other drugs from the classes listed above. The side effects of the foregoing medications include severe skin irritation, sensitivity to the sun, suppression of the immune system, anemia and kidney problems. For example, psoriasis and eczema may be treated with drugs such as topical corticosteroids, immunomodulators, such as tacrolimus and pimecrolimus, immune suppressants, such as cyclosporine azathioprine and methotrexate, and biological agents, such as antibodies. However, many of these medications have serious side effects. Many dermatological disorders are chronic disorders that may only be managed by long-term administration, and even lifetime administration, of various medications. The entire contents of the foregoing applications are hereby incorporated by reference.
21, 2012, which claims the benefit of U.S.
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